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Insulin-stimulated glucose uptake in skeletal muscle, adipose

If you have type 2 diabetes and your doctor thinks it might be a good time to start insulin therapy, there are two important factors to consider: How much insulin do you need to take? When do you need to take it? And both are very personal. If you need insulin for diabetes, there’s good news: You have choices. There are five types of insulin.

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In addition, chemerin potentiated insulin‐stimulated glucose uptake in the 3T3‐L1 adipocytes concomitant with enhancing insulin signaling. These data suggest pathophysiological significance of chemerin in obesity and diabetes. It is also demonstrated that chemerin is a novel adipokine that regulates insulin sensitivity in adipose tissue. Insulin-mediated effects on GLUT4 cell surface translocation (Fig. 6b) and subsequent glucose uptake mostly disappeared in palmitate-treated adipocytes (Fig.

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These lipids also exert anti‐inflammatory effects. An important functional characteristic of adipocytes, including brown adipocytes, is insulin-dependent glucose uptake.

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Methods in Molecular Biology™, vol 83. Shikonin stimulated glucose uptake and potentiated insulin-stimulated glucose uptake in a concentration-dependent manner in 3T3-L1 adipocytes. Stimulation of glucose uptake was also observed in rat primary adipocytes and cardiomyocytes. Resveratrol (Res) is a natural polyphenolic compound with anti-inflammatory and antioxidative effects. However, effects and mechanisms of Res on glucose metabolism in adipocytes remain largely unknown. In this study, we show Res treatment significantly increases glucose uptake in insulin-resistant 3T3-L1 adipocytes in vitro. Insulin stimulated GLUT4 (glucose transporter 4) translocation and glucose uptake in muscles and adipocytes is important for the maintenance of blood glucose homeostasis in our body.

MJ Honka, A Latva-Rasku, Marco Bucci,  Influence of insulin on glucose metabolism and lipolysis in adipose tissue in situ in response to insulin, is at hand with a glucose uptake into the adipocytes of  av C Nowak · 2018 · Citerat av 23 — In mouse 3T3-L1 adipocytes exposed to different acylcarnitines, we observed blunted insulin-stimulated glucose uptake after treatment with C10- or C12-carnitine. av R Westergren · 2010 · Citerat av 1 — Ahrén B, Enerback S. Overexpression of Foxf2 in adipose tissue is associated with lower transgenic mice have an impaired insulin-mediated glucose uptake. av B Keselman · 2017 · Citerat av 16 — Results Insulin and cortisol levels were higher, and insulin sensitivity was Insulin induces glucose uptake in fat cells and in muscle cells by  Adipocyte glucose uptake and adipogenesis remained unchanged between adipose tissue: a role for estrogen receptor β pathway in insulin resistance? 3.
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Insulin uptake in adipocytes

Furthermore, insulin sensitivity in  To clear the high sugar levels in the blood stream, insulin is an important target of rapamycin in muscle and adipose tissue · Glucose uptake in brown fat cells. Keywords : cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake;  Uppmätt mätning av glukos och reaktion på insulinstimulering i doi: Kjeldsen, S. E. Insulin sensitivity relates to other cardiovascular risk factors in young insulin receptor substrate 1 protein depletion in human adipocytes. av P Björntorp · 1972 · Citerat av 318 — oxygen uptake, plasma lipids, glucose and lipid tolerance, and plasma insulin men were characterized by a small adipose tissue consisting of small fat cells,  and lipid metabolism in insulin resistance an experimental study in fat cells.

These lipids also exert anti‐inflammatory effects. An important functional characteristic of adipocytes, including brown adipocytes, is insulin-dependent glucose uptake. Insulin-induced glucose uptake in our cell lines was dose-responsive with a submaximal, approximately 6-fold increase at an insulin concentration of 10 n m (Fig.
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Novel aspects of metabolic regulation and inflammation in

and evaluate the molecular response in skeletal muscle and adipose tissue. Fatty acid uptake in key tissues will be determined by functional imaging (PET-MRI). for lean tissue changes, ectopic fat accumulation and insulin resistance. The protein has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases AKT phosphorylation in the  av C Saloranta — Denna s.k. metabola resistens kan antingen vara hela förklaringen till ett insulinresistent tillstånd uptake and esterification in adipose tissue.