Cerebral small vessel disease - preparing for RCT

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The Fazekas-scale provides an overall impression of the presence of WMH in the entire brain. It is best scored on transverse FLAIR or T2-weighted images. On the FLAIR images, we applied the visual rating scales of Fazekas (range 0 to 3), Scheltens (range 0 to 84), and the Age-Related White Matter Changes (ARWMC) scale (range 0 to 30).15–17 All ratings were performed by an experienced rater (E.vS.) blind to the clinical data. Volumetric Assessment L O Wahlund 1 , F Barkhof, F Fazekas, L Bronge, M Augustin, M Sjögren, A Wallin, H Ader, D Leys, L Pantoni, F Pasquier, T Erkinjuntti, P Scheltens, European Task Force on Age-Related White Matter Changes Participants obtained a T2-weighted scan as well as a positron emission tomography scan using (11)[C] Pittsburgh Compound B. Periventricular white matter hyperintensities (PVWMHs) and deep white matter hyperintensities (DWMHs) were measured on each T2 scan using the Fazekas rating scale. To test the hypothesis that lesion type (punctate, defined as Fazekas score 1, versus confluent, defined as Fazekas score 3, with comparable lesion volumes) was associated with clinical characteristics, we selected all subjects with WMH volume between 15 and 30 mL. In this volume range, both Fazekas scores 1 and 3 were represented. Each 1 score increase in Fazekas score was associated with an adjusted odds ratio (95% CI) of 1.25 (1.03-1.51) for 14 days or hospital discharge and 1.39 (1.12-1.72) for 3-month functional outcome.

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Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities. Artikel i vetenskaplig tidskrift, refereegranskad. Författare.

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We investigated associations between three commonly used measurements of WMSA, aiming to further understand the association between them and their potential interchangeability: the Fazekas scale, the lesion segmentation tool (LST), and FreeSurfer. On MR, white matter hyperintensities (WMH) and lacunes - both of which are frequently observed in the elderly - are generally viewed as evidence of small vessel disease. The Fazekas-scale provides an overall impression of the presence of WMH in the entire brain. It is best scored on transverse FLAIR or T2-weighted images. On the FLAIR images, we applied the visual rating scales of Fazekas (range 0 to 3), Scheltens (range 0 to 84), and the Age-Related White Matter Changes (ARWMC) scale (range 0 to 30).15–17 All ratings were performed by an experienced rater (E.vS.) blind to the clinical data. Volumetric Assessment L O Wahlund 1 , F Barkhof, F Fazekas, L Bronge, M Augustin, M Sjögren, A Wallin, H Ader, D Leys, L Pantoni, F Pasquier, T Erkinjuntti, P Scheltens, European Task Force on Age-Related White Matter Changes Participants obtained a T2-weighted scan as well as a positron emission tomography scan using (11)[C] Pittsburgh Compound B. Periventricular white matter hyperintensities (PVWMHs) and deep white matter hyperintensities (DWMHs) were measured on each T2 scan using the Fazekas rating scale. To test the hypothesis that lesion type (punctate, defined as Fazekas score 1, versus confluent, defined as Fazekas score 3, with comparable lesion volumes) was associated with clinical characteristics, we selected all subjects with WMH volume between 15 and 30 mL.